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Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
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Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

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DISINFECTION OF AEROSOLIZED PATHOGENIC FUNGI ON LABORATORY SURFACES. I. TISSUE PHASE

R H KRUSE, T D GREEN, R C CHAMBERS

    Applied Microbiology
    |September 1, 1963
    PubMed

    Insights

    Fungicides effectively eliminate pathogenic fungi like Blastomyces dermatitidis on lab surfaces. Surface type impacts efficacy, but concentration and time can be adjusted for disinfection.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Laboratory Safety

    Background:

    • Pathogenic fungi pose risks in laboratory settings.
    • Effective decontamination protocols are crucial for preventing fungal transmission.

    Purpose of the Study:

    • To evaluate the efficacy of various fungicides against common pathogenic fungi.
    • To determine the influence of surface type on fungicidal activity.
    • To provide guidance for laboratory disinfection procedures.

    Main Methods:

    • Testing multiple fungicides against the tissue phase of Blastomyces dermatitidis, Coccidioides immitis, Cryptococcus neoformans, and Histoplasma capsulatum.
    • Statistical analysis correlating fungi, surfaces, time, and disinfectant concentration.
    • Assessing efficacy on various laboratory surfaces.

    Main Results:

    • All tested fungicides demonstrated effectiveness at specified concentrations and times.
    • The type of laboratory surface significantly influenced fungicidal efficacy.
    • Data allowed for interpolation to determine optimal disinfection parameters.

    Conclusions:

    • Fungicides are effective for decontaminating laboratory surfaces from pathogenic fungi.
    • Adjusting fungicide concentration and exposure time based on surface type is necessary for optimal disinfection.
    • This study provides a framework for safe laboratory practices when handling pathogenic fungi.
    Keywords:
    ANTIFUNGAL AGENTSBLASTOMYCESCOCCIDIOIDESCRYPTOCOCCUSEXPERIMENTAL LAB STUDYFUNGIHISTOPLASMALABORATORIESPHARMACOLOGYSTERILIZATION

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