Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

First-trimester exposure to alprazolam.

S M St Clair1, R G Schirmer

  • 1Worldwide Pharmacovigilance II Unit, Upjohn Company, Kalamazoo, Michigan.

Obstetrics and Gynecology
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of spontaneous reporting system data.

Archives of internal medicine·1992
Same author

Exposure to benzodiazepines in utero.

Lancet (London, England)·1987
Same author

Peripheral lymphocyte function in dogs with Brucella canis infection.

Veterinary immunology and immunopathology·1983
Same author

Tracheal osteochondroma in a dog.

Journal of the American Veterinary Medical Association·1977
Same author

Canine actinomycosis due to Actinomyces viscosus: report of six cases.

Veterinary medicine, small animal clinician : VM, SAC·1974
Same author

Mucoperiosteal flap technique for cleft palate repair in dogs.

Journal of the American Veterinary Medical Association·1974
Same journal

The Political Determinants of Obstetric Prescribing.

Obstetrics and gynecology·2026
Same journal

Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis.

Obstetrics and gynecology·2026
Same journal

Milestones in Motion: Vaginal Birth After Cesarean.

Obstetrics and gynecology·2026
Same journal

Ebola Virus in Pregnancy.

Obstetrics and gynecology·2026
Same journal

A Quality-Improvement Study Evaluating Three Postpartum Prophylactic Oxytocin Rates and Blood Loss After Vaginal Birth.

Obstetrics and gynecology·2026
Same journal

The Effects of Climate Change on Obstetric and Gynecologic Health.

Obstetrics and gynecology·2026
See all related articles

This study found no clear pattern of birth defects or increased spontaneous abortions in pregnancies exposed to alprazolam during the first trimester. However, more research is needed to definitively confirm the safety of alprazolam during pregnancy.

Area of Science:

  • Perinatal medicine
  • Pharmacology
  • Teratology

Background:

  • First-trimester exposure to medications during pregnancy requires careful risk assessment.
  • Alprazolam, a benzodiazepine, is commonly prescribed and its prenatal safety profile needs ongoing evaluation.

Purpose of the Study:

  • To prospectively evaluate pregnancy outcomes following first-trimester exposure to alprazolam.
  • To identify any early signals of potential drug-related fetal risks.

Main Methods:

  • Prospective registration of first-trimester alprazolam exposures from patients, physicians, and pharmacists.
  • Follow-up data collection on drug exposure, risk factors, and pregnancy outcomes at 4.5 and 9 months post-registration.

Main Results:

Related Experiment Videos

  • Data from 542 registered pregnancies (411 with follow-up) between 1982-1990.
  • Observed outcomes included 13 live births with congenital anomalies, 263 live births without anomalies, 47 spontaneous fetal losses, and 88 elective abortions.

Conclusions:

  • No discernible pattern of birth defects or increased spontaneous abortions was observed.
  • The current sample size is insufficient to definitively conclude on the safety of alprazolam for pregnant women and fetuses.
  • Further research is necessary to confirm or refute previous reports linking benzodiazepine exposure to specific congenital anomalies.