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[Captopril-induced toxic hepatitis].

J H Pedersen1, P S Clementsen, S Høyer

  • 1Hepatologisk afdeling A, Rigshospitalet, København.

Ugeskrift for Laeger
|October 12, 1992
PubMed
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Captopril, an angiotensin-converting enzyme inhibitor, can cause liver injury. This case highlights the rare but serious risk of Captopril-induced hepatic injury, even after drug discontinuation, emphasizing clinical vigilance.

Area of Science:

  • Pharmacology
  • Hepatology
  • Nephrology

Background:

  • Captopril is a widely used angiotensin-converting enzyme (ACE) inhibitor for hypertension and heart failure.
  • Adverse reactions to Captopril are generally infrequent, with hepatic injury not commonly reported in some regions like Denmark.
  • However, global reports indicate a potential for Captopril-induced liver damage.

Observation:

  • A case of Captopril-induced hepatic injury is presented.
  • The patient developed hepatorenal syndrome despite ceasing Captopril treatment.
  • The patient unfortunately died five weeks post-admission.

Findings:

  • Captopril can lead to severe hepatic injury.
  • Hepatorenal syndrome can occur as a complication of Captopril-induced liver damage.

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  • The adverse effects of Captopril on the liver may persist even after drug withdrawal.

    • Implications:

    • Clinicians should maintain a high index of suspicion for Captopril-induced hepatic injury.
    • Awareness of this potential adverse reaction is crucial for patient safety.
    • Prompt recognition and management may be necessary to mitigate severe outcomes.