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Cerebral aspergillosis: MR imaging and histopathologic correlation.
J Cox1, F R Murtagh, A Wilfong
1Department of Radiology, University of South Florida College of Medicine, Tampa 33612.
AJNR. American Journal of Neuroradiology
|September 1, 1992
Summary
This case study details intracranial aspergillosis in an immunosuppressed patient. Brain MRI findings correlated with autopsy, revealing Aspergillus hyphae and hemorrhage in a low-signal intensity ring.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Intracranial aspergillosis is a rare but severe fungal infection.
- Immunosuppression is a primary risk factor, increasing susceptibility to opportunistic infections like aspergillosis.
Observation:
- A case of intracranial aspergillosis is presented in a patient with a history of immunosuppression.
- Brain Magnetic Resonance (MR) imaging was utilized to visualize the lesion.
Findings:
- Signal intensity changes on brain MR were analyzed and compared with autopsy findings.
- A peripheral low signal intensity ring in the lesion was identified.
- This ring corresponded to a dense concentration of Aspergillus hyphal elements and microhemorrhages.
- Computed Tomography (CT) findings were also included for comparative analysis.
Implications:
- This study highlights the importance of recognizing characteristic imaging findings of intracranial aspergillosis.
- Correlation of imaging with histopathology aids in understanding the pathophysiology of the disease.
- Early diagnosis and treatment are crucial for improving outcomes in immunosuppressed patients with suspected fungal brain infections.