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The effects of deprenyl on methamphetamine-induced dopamine depletions
S K Johnson1, D Medina, G C Wagner
1Department of Psychology, Rutgers University, New Brunswick, NJ.
Journal of Neural Transmission. General Section
|January 1, 1992
Abstract:
The effects of deprenyl on methamphetamine-induced dopamine depletions were studied in mice. Four SC injections of 12.5 mg/kg of methamphetamine at two-hour intervals caused substantial (72-82%) and long-lasting depletions of striatal dopamine. Pretreatment with either 25 or 40 mg/kg of deprenyl did not significantly alter the magnitude of this depletion. These results indicate that, unlike what is observed following MPTP, there is no protection afforded dopaminergic cells by deprenyl pretreatment in the methamphetamine model of parkinsonism.