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Bone infarct-associated osteosarcoma.

F X Torres1, M Kyriakos

  • 1Lauren V. Ackerman Division of Surgical Pathology, Washington University School of Medicine, St. Louis, Missouri.

Cancer
|November 15, 1992
PubMed
Summary
This summary is machine-generated.

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Infarct-associated sarcoma (IAS) is a rare bone cancer. Osteosarcoma arising from bone infarcts has a poor prognosis, with most patients succumbing to the disease.

Area of Science:

  • Orthopedic Oncology
  • Bone Pathology
  • Sarcoma Research

Background:

  • Infarct-associated sarcoma (IAS) of bone is a rare malignancy.
  • This study reviews documented cases of IAS, focusing on osteosarcoma arising in bone infarcts.

Observation:

  • A case of osteosarcoma developing in a medullary infarct of the humerus is presented.
  • A collective review identified 37 fully documented IAS cases, with 26 men and 12 women aged 18-82.
  • Black patients were disproportionately represented (36%).

Findings:

  • Most infarcts had no known cause; common associations included dysbaric events or alcoholism.
  • The femur (21 cases) and tibia (14 cases) were most frequently involved.
  • Osteosarcoma constituted 18.4% of IAS cases, with malignant fibrous histiocytoma being more common (72.5%).

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Implications:

  • IAS, particularly osteosarcoma, carries a poor survival rate, with high mortality.
  • Five of seven osteosarcoma patients (71%) and 20 of 31 other IAS patients (65%) died from their tumors.
  • Long-term survival (over 5 years) was observed in eight patients.