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Updated: Jul 29, 2026

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Published on: April 27, 2018
Tissue-specific localization of mitochondrial imidazoline-guanidinium receptive sites
1C.N.R.S. URA 1482, Laboratoire de Pharmacologie, CHU Necker, Paris, France.
Abstract:
In the present report, we studied the distribution of the imidazoline-guanidinium receptive site in mitochondrial fractions from different rabbit and human tissues. Binding studies of the imidazoline-guanidinium receptive site ligand [3H]idazoxan, allowed to distinguish two groups of tissues: the first one, including kidney, brain and liver, displays a high density of imidazoline-guanidinium receptive site; the second one, consisting of striated and smooth muscle, enterocytes, lung, spleen and heart, is characterized by 4- to 16-fold lower binding site density. The demonstration that mitochondrial imidazoline-guanidinium receptive sites are not equally expressed in all tissues can be considered as a further progress towards the characterization of their functional activity.
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