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Buspirone-associated mental status changes.

P Soni1, A L Weintraub

  • 1Valley Mental Health's Adolescent Residential Treatment and Education Center, Kearns, Utah.

Journal of the American Academy of Child and Adolescent Psychiatry
|November 1, 1992
PubMed
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Buspirone, an atypical anxiolytic, is used for childhood anxiety. However, two cases show potential psychotic deterioration after buspirone treatment, warranting further investigation into this adverse effect.

Area of Science:

  • Child and Adolescent Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • Pharmacological management of childhood anxiety often involves antidepressants like imipramine.
  • Buspirone, an atypical anxiolytic, has demonstrated efficacy in both adult and pediatric populations.
  • Buspirone is generally well-tolerated with a favorable side effect profile.

Observation:

  • Two pediatric cases are presented involving treatment with buspirone for anxiety.
  • Following buspirone administration, both children experienced a possible psychotic deterioration.
  • This observation suggests a potential adverse reaction to buspirone in susceptible children.

Findings:

  • The reported cases highlight a potential link between buspirone use and the emergence of psychotic symptoms in children.

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  • This contrasts with the generally accepted safety profile of buspirone in pediatric populations.
  • Further research is needed to understand the mechanisms and prevalence of this adverse effect.

    • Implications:

    • Clinicians should exercise caution when prescribing buspirone for anxiety in children.
    • Monitoring for psychotic symptoms during buspirone treatment is crucial.
    • These findings necessitate a re-evaluation of buspirone's risk-benefit ratio in pediatric anxiety management.