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Donor reactions during DDAVP-stimulated plasmapheresis
M J Randels1, R G Strauss, D Cordle
1Elmer L. DeGowin Memorial Blood Center, University of Iowa Hospitals and Clinics, Iowa City 52242.
Journal of Clinical Apheresis
|January 1, 1992
Summary
DDAVP-stimulated plasma exchange donation is a safe and effective method for collecting large volumes of potent cryoprecipitated antihemophilic factor (AHF). This approach reduces donor exposure for patients with hemophilia A and von Willebrand disease.
Area of Science:
- Hematology
- Transfusion Medicine
Background:
- Classical hemophilia A and von Willebrand disease require potent cryoprecipitated antihemophilic factor (AHF).
- Reducing donor exposure is crucial for managing these conditions.
Purpose of the Study:
- To evaluate the safety and efficacy of DDAVP-stimulated plasma exchange donation for collecting large volumes of AHF.
- To assess donor reactions and procedural modifications during this process.
Main Methods:
- 20 donors underwent 48 procedures involving DDAVP (1-deamino-8-D-arginine vasopressin) stimulation followed by 2-3 L plasma collection.
- Plasma protein fraction was used as replacement fluid for initial donations; autologous cryoprecipitate-poor plasma for subsequent ones.
Main Results:
- All 48 procedures resulted in mild reactions, primarily facial flushing.
- Four procedures were modified due to pulse rate increase or blood pressure decrease; none were discontinued.
- No donors were deferred or withdrew, indicating good tolerability.
Conclusions:
- DDAVP-stimulated plasma exchange donation is a safe and effective method for collecting potent cryoprecipitated AHF.
- This procedure can significantly reduce donor exposure for patients with hemophilia A and von Willebrand disease.