Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Levodopa and childhood amblyopia.

L E Leguire1, G L Rogers, D L Bremer

  • 1Department of Ophthalmology, Children's Hospital, Columbus, Ohio 43205.

Journal of Pediatric Ophthalmology and Strabismus
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4.

Haemophilia : the official journal of the World Federation of Hemophilia·2014
Same author

Inferior rectus muscle fibrosis following orbital trauma.

Journal of pediatric ophthalmology and strabismus·2014
Same author

Relationship among fMRI, contrast sensitivity and visual acuity.

Brain research·2010
Same author

Epilepsy and the concentrations of plasma amino acids in humans.

Neurochemistry international·2010
Same author

Control of cross-talk effects with pulse-width modulated pictures on orthogonal carriers.

Applied optics·2010
Same author

Construction of a phase-inverting grating and its use in a deblurring filter.

Applied optics·2010
Same journal

TeleROP-NI: Modernizing Retinopathy of Prematurity Screening in Northern Ireland to Enhance Decision-making and Ensure Sustainability.

Journal of pediatric ophthalmology and strabismus·2026
Same journal

Ocular Microstructural Alterations in Children With Spina Bifida: An Optical Coherence Tomography Study.

Journal of pediatric ophthalmology and strabismus·2026
Same journal

Systemic Inflammatory Markers and Their Relationship With Optic Nerve Head Alterations in Pediatric Idiopathic Intracranial Hypertension.

Journal of pediatric ophthalmology and strabismus·2026
Same journal

Evaluating Large Language Models to Improve Spanish Patient Education on Childhood Glaucoma.

Journal of pediatric ophthalmology and strabismus·2026
Same journal

Comparative Evaluation of Unilateral Recession-Plication Versus Bilateral Three-Muscle Surgery for Large-Angle Exotropia.

Journal of pediatric ophthalmology and strabismus·2026
Same journal

Long-term Visual Sequelae of Shaken Baby Syndrome: A Retrospective Study of 52 Cases.

Journal of pediatric ophthalmology and strabismus·2026
See all related articles

Levodopa/carbidopa temporarily improved vision in older children with amblyopia, but side effects like nausea were common. Further trials are needed for this potential amblyopia treatment.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Amblyopia, or "lazy eye," often persists in older children despite conventional treatments like occlusion therapy.
  • Exploring novel pharmacological interventions is crucial for refractory amblyopia cases.

Purpose of the Study:

  • To evaluate the safety and efficacy of levodopa/carbidopa in treating amblyopia in children resistant to standard therapies.
  • To assess the pharmacokinetic profile and visual function improvements following drug administration.

Main Methods:

  • A pilot study involving five amblyopic children (7-12 years) and two adults receiving escalating doses of levodopa/carbidopa.
  • Monitoring of vital signs, adverse events, and blood samples for pharmacokinetic analysis.
  • Assessment of visual acuity, contrast sensitivity, stereo acuity, and pattern visual evoked responses (VERs).

Related Experiment Videos

Main Results:

  • Significant temporary improvements in Snellen visual acuity (20/159 to 20/83) and contrast sensitivity were observed in amblyopic eyes.
  • Pharmacokinetics showed peak levodopa serum levels within 1 hour, with a 50% decrease by 2-4 hours.
  • High incidence of side effects, including nausea and emesis (4/7 subjects), and transient visual function improvements lasting up to 5 hours.

Conclusions:

  • Levodopa/carbidopa demonstrated temporary visual function enhancement in older amblyopic children.
  • The drug's tolerability and side effect profile require careful consideration for future therapeutic development.
  • Results support the rationale for a larger clinical trial investigating levodopa/carbidopa for childhood amblyopia.