Related Experiment Videos
[Mechanism of cytokine pleiotropy and mutual regulation]
1Dept. of Biomolecular Science, Faculty of Science, Toho University.
Cytokines manifest overlapping effects on many cell types and their production is regulated by a cytokine network. This minireview summarizes the current understanding of how affinity converter molecules, shared by several cytokines, is related to cytokine pleiotropy, and how Th1/Th2 are differentially developed and regulated through a cytokine network, especially, negative loop. Finally, the importance of the temporal expression of cytokines, in relation to the physiological relevance of the network, is pointed out.
Cytokines manifest overlapping effects on many cell types and their production is regulated by a cytokine network. This minireview summarizes the current understanding of how affinity converter molecules, shared by several cytokines, is related to cytokine pleiotropy, and how Th1/Th2 are differentially developed and regulated through a cytokine network, especially, negative loop. Finally, the importance of the temporal expression of cytokines, in relation to the physiological relevance of the network, is pointed out.