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Enhanced chromosomal fragility in neuroblastoma: correlation with poor prognosis

P Vernole1, B Tedeschi, G Melino

  • 1Department of Public Health and Cell Biology, 2nd University of Rome, Italy.

Anticancer Research
|September 1, 1992
PubMed

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...