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Changes in membrane fluidity during human liver development.

B G Devi1, P D Gupta, C M Habeebullah

  • 1Department of Gastroenterology, Osmania General Hospital, Hyderabad, India.

Biochemistry International
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

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Human liver plasma membrane fluidity decreases with development. This maturation involves changes in lipid composition, impacting membrane function during prenatal growth and into adulthood.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Developmental Biology

Background:

  • The hepatic plasma membrane undergoes significant changes during development.
  • Understanding these changes is crucial for comprehending liver function and differentiation.

Purpose of the Study:

  • To investigate the physico-chemical properties of the hepatic plasma membrane during human prenatal development and in adult liver.
  • To correlate changes in membrane composition with alterations in membrane fluidity and function.

Main Methods:

  • Fluorescence polarization studies using the lipid probe pyrene.
  • Detailed lipid analysis of hepatic plasma membrane samples.

Main Results:

  • A significant reduction in membrane fluidity was observed with liver maturation.

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  • Age-dependent decrease in lipid/protein ratio and an increase in membrane cholesterol were noted.
  • Changes in phospholipid ratios (decreased phosphatidylcholine/phosphatidylethanolamine, increased sphingomyelin/phosphatidylcholine) were identified.

    • Conclusions:

    • Gradual decrease in lipid content and membrane fluidity occurs during prenatal development.
    • These changes likely regulate the differentiation of membrane-associated functions in the human liver.