[Genetics of coronary heart disease]

Coronary heart disease (CHD) is among the leading causes for invalidity and death in industrialized countries. A prominent role of genetic factors in the onset of this disease has been documented in twin and family studies, by the use of experimental animal models, and by unravelling the genetic basis of monogenic disorders closely associated with CHD. Notwithstanding this knowledge attempts have failed to significantly improve prediction, early diagnosis and treatment of the common disorder CHD. The following will discuss the reasons for this lack of success but argue for positive perspectives that are ahead of us.