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Titanocene(III)-promoted Reformatsky additions
J D Parrish1, Daniel R Shelton, R Daniel Little
1Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, California 93106-9510, USA.
Organic Letters
|September 26, 2003
Abstract:
[reaction: see text] A novel method for the promotion of Reformatsky-like reactions is presented. The technique employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are rapid, operationally simple, and compatible with a wide range of functionalities. These additions are also anti diastereoselective.