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Subungual pleomorphic fibroma.

Ya-Ju Hsieh1, Yang-Chih Lin, Yu-Hung Wu

  • 1Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.

Journal of Cutaneous Pathology
|September 26, 2003
PubMed
Summary
This summary is machine-generated.

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This case report details a rare subungual pleomorphic fibroma, a benign tumor that can mimic malignancy. Early diagnosis and treatment are crucial for managing this unusual cutaneous neoplasm.

Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Pleomorphic fibroma is a benign fibroblastic tumor with cytologic features that can be mistaken for malignancy.
  • Typically found on the trunk or extremities, subungual presentation is rare.

Observation:

  • A 66-year-old woman presented with a 40-year history of a subungual mass on the left middle finger causing nail deformity.
  • Histopathology revealed a paucicellular tumor with pleomorphic, hyperchromatic cells and giant multinucleated cells in a collagenous stroma.
  • Immunohistochemistry showed vimentin positivity and negative staining for S-100, cytokeratin, smooth muscle actin, factor XIIIa, and CD34.

Findings:

  • The tumor was diagnosed as a pleomorphic fibroma based on its distinct histologic and immunohistochemical profile.

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  • No mitotic figures were observed, supporting its benign nature despite atypical cellular morphology.
  • The patient showed no evidence of recurrence 36 months post-excision.

    • Implications:

    • Subungual pleomorphic fibroma is an uncommon cutaneous tumor with potential for misdiagnosis as sarcoma.
    • This report highlights the second documented case of subungual pleomorphic fibroma.
    • Consideration of pleomorphic fibroma in the differential diagnosis of subungual tumors is essential for accurate patient management.