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[Comparative effectiveness of flupenthixol and risperidone on negative symptoms of schizophrenia]
Michael Philipp1, Otto M Lesch, Max Schmauss
1Bezirkskrankenhaus Landshut, Prof.-Buchner-Strasse 22, 84034 Landshut.
Abstract:
The efficacy of flupentixol and risperidone were compared in a randomized double-blind study in 153 chronic schizophrenic patients. Flupentixol showed to be not inferior to risperidone concerning schizophrenic negative symptoms at week 8, 16 and 24. Positive symptoms and general psychopathology improved comparably, too. There was a trend in favor of flupentixol concerning the improvement of depressive symptoms and a trend in favor of risperidone concerning the improvement of preexisting parkinsonian symptoms. The study data justify to regard flupentixol as a "partial atypical" antipsychotic.
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