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Palladium-catalyzed H-D exchange into nucleic acids in deuterium oxide
Hironao Sajiki1, Fumiyo Aoki, Hiroyoshi Esaki
1Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.
Nucleic Acids Research. Supplement (2001)
|September 27, 2003
Abstract:
We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleic acids. The results presented here provide a deuterium gas-free, totally catalytic and post-synthetic deuterium labeling method in D2O media.