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Updated: Aug 25, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
A new synthetic approach to cyclic bis(3'-->5')diguanylic acid
Rie Kawai1, Reiko Nagata, Akiyoshi Hirata
1Graduate School of Human Informatics, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
Abstract:
We developed a novel synthesis of biologically important cyclic bis(3'-->5')diguanylic acid (cGpGp). The present synthesis includes two strategies different from those employed in an existing synthesis. They are the phosphoramidite method for the preparation of a guanylyl(3'-->5')guanylic acid intermediate and allyl protection for guanine bases and internucleotide linkages. These distinctive strategies have allowed the new synthesis to provide the target compound in a higher yield than that of the existing synthesis.
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