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Updated: Aug 9, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
[Late-onset Wilsońs disease]
J Campos Franco1, M J Domínguez Santalla, S Tomé Martínez de Rituerto
1Servicio de Medicina Interna. Hospital Clínico. Complejo Universitario Santiago de Compostela. A Coruña, Spain. xkampos@hotmail.com
Abstract:
A 58-year old male with a past history of psychiatric disorders was studied for a persistent serum transaminase increase. Low serum ceruloplasmin level (lower than 3 mg/dL), increased urinary copper excretion, and increased liver tissue copper concentration (1050 mcg/g dry weight) confirmed the diagnosis of Wilsońs disease. Slit lamp examination did not show Kayser-Fleischer rings. D-penicilamin therapy was followed by serum transaminase normalization. Similar late-onset cases of Wilsońs disease are exceptional, but confirm the clinical heterogeneity of the disease.
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