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Model Interpretation and Clinical Implications.

Joseph A. Thie¹, Karl F. Hubner, Gary T. Smith

¹Biomedical Imaging Center, Department of Radiology, The University of Tennessee Medical Center at Knoxville, Knoxville, TN, USA

Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T

|October 1, 2003

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Positron emission tomography (PET) standardized uptake values (SUV) and influx constants (K) can characterize cancer. Tracer clearance time (T) is independent of cancer type, offering a reliable diagnostic marker.

Area of Science:

Nuclear Medicine
Radiochemistry
Oncology

Background:

Positron emission tomography (PET) imaging uses standardized uptake values (SUV) and influx constants (K) to characterize tumors.
Historical data from 30 PET oncological studies were analyzed to derive useful parameters.

Purpose of the Study:

To investigate the relationship between SUV and K in oncological PET studies.
To determine if tracer clearance time (T) is a reliable cancer characteristic.

Main Methods:

Meta-analysis of 30 multipatient PET oncological studies.
Calculation of SUV vs. K correlation coefficients and SUV/K ratios.
Monte Carlo simulation to model tracer clearance.

Main Results:

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High correlation coefficients (0.89 for FDG, 0.80 for L-methionine) between SUV and K were observed.
Average tracer clearance times (T) were 192 minutes for FDG and 63 minutes for L-methionine.
Coefficients of variation for K were larger than for SUV, suggesting K is more sensitive to biological variability.

Conclusions:

Tracer clearance time (T) is a characteristic parameter independent of cancer type.
Higher variability in K compared to SUV suggests K may be a more sensitive diagnostic marker.
SUV conversions to K can aid in quality assurance for K measurements.