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Updated: Aug 30, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Caged oxoanions
Vickie McKee1, Jane Nelson, Raewyn M Town
1Chemistry Department, Loughborough University, UK LE11 3TU.
Abstract:
The association between azacryptand hosts and oxoanion guests is reviewed. Positively charged hosts are the most effective; we focus on protonated azacryptands. Assessment of quantitative data suggests an anion cryptate effect and provides clear evidence for charge-based selectivity. Crystal structures show both cavity and cleft binding sites for anions within the series of cryptands studied. These two binding modes exhibit different pH dependence offering the possibility for design of monitoring/clean-up strategies based on a variation of appropriate host(s) and pH conditions.
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