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Finding NEMO: genetic disorders of NF-[kappa]B activation

Jordan S Orange1, Raif S Geha

  • 1Division of Immunology, Children's Hospital, Boston, Massachusetts, USA.

The Journal of Clinical Investigation
|October 3, 2003
PubMed

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...