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Related Experiment Videos

Serum tumor markers.

Greg L Perkins1, Evan D Slater, Georganne K Sanders

  • 1Ventura County Medical Center, Ventura, California, USA. gperkins@mcfarlandclinic.com

American Family Physician
|October 4, 2003
PubMed
Summary
This summary is machine-generated.

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Tumor markers, detected by monoclonal antibodies, are valuable for monitoring cancer therapy response and relapse. However, most lack the sensitivity for effective cancer screening, with exceptions like prostate-specific antigen (PSA).

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Monoclonal antibodies enable detection of serum antigens linked to malignancies.
  • These tumor markers primarily aid in monitoring therapeutic response and early relapse detection.
  • Most tumor markers lack the necessary sensitivity and specificity for widespread cancer screening.

Purpose of the Study:

  • To review the clinical utility of various serum tumor markers in oncology.
  • To highlight the applications of specific tumor markers in different cancer types.
  • To discuss the limitations of tumor markers in cancer screening versus monitoring.

Main Methods:

  • Literature review of studies utilizing monoclonal antibody-based tumor markers.
  • Analysis of clinical applications for specific tumor markers including CA 27.29, CEA, CA 19-9, CA 125, AFP, beta-hCG, and PSA.

Related Experiment Videos

  • Evaluation of marker utility in screening, diagnosis, therapy monitoring, and recurrence detection.

    • Main Results:

    • Cancer antigen (CA) 27.29 is used for metastatic breast cancer therapy monitoring.
    • Carcinoembryonic antigen (CEA) aids in colorectal cancer relapse detection; CA 19-9 assists in pancreatic mass evaluation.
    • CA 125 is useful for ovarian cancer management, AFP for hepatocellular carcinoma, beta-hCG for gestational trophoblastic disease, and PSA for prostate cancer.

    Conclusions:

    • Tumor markers are essential for monitoring treatment efficacy and detecting cancer recurrence.
    • While some markers like PSA show screening utility, most are not suitable for general population screening.
    • Combined markers like AFP and beta-hCG are crucial for specific germ cell tumors and undifferentiated metastatic cancers.