Related Experiment Videos
[Herpes simplex keratitis after ophthalmic surgery]
Seiya Miyajima1, Yoichiro Sano, Chie Sotozono
1Department of Ophthalmology, Kyoto Prefectural University of Medicine, 456 Kajii-cho, Kawaramachi, Kamigyo-ku, Kyoto 602-0841, Japan.
Nippon Ganka Gakkai Zasshi
|October 9, 2003
Summary
Ophthalmic surgery can trigger herpes simplex keratitis, even without prior history. Prompt diagnosis using PCR in tear fluid and treatment with acyclovir are crucial for healing these infections.
Area of Science:
- Ophthalmology
- Virology
- Infectious Diseases
Context:
- Herpes simplex keratitis (HSK) is a significant cause of corneal blindness.
- Ophthalmic surgery can precipitate HSK in susceptible individuals.
- Corticosteroid use post-surgery is a known risk factor for HSK.
Purpose:
- To report 6 cases of HSK following ophthalmic surgery in patients with no prior history.
- To identify clinical findings and predisposing factors for post-operative HSK.
- To evaluate the utility of PCR in diagnosing HSK in this context.
Summary:
- Six cases of HSK occurred after ophthalmic procedures (keratoplasty, cataract surgery).
- Predisposing factors included corticosteroid therapy and surgical wounds.
- Herpes simplex virus (HSV)-DNA was detected via PCR in tear fluid for all patients.
- Lesions varied (dendritic, geographic, atypical ulcers) and healed with oral/topical acyclovir.
Impact:
- Highlights the risk of HSK post-ophthalmic surgery, especially with corticosteroid use.
- Emphasizes the importance of considering HSK in patients with no prior history.
- Demonstrates the diagnostic value of PCR for HSV-DNA in tear fluid for HSK.