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Fetal hydrocephalus.

George H Davis1

  • 1Division of Maternal-Fetal Medicine, Section of Fetal Diagnosis and Therapy, Vanderbilt University Medical Center, VUMC B-1100, MCN Nashville, TN 37232-2519, USA. george.davis@vanderbilt.edu

Clinics in Perinatology
|October 10, 2003
PubMed
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Fetal hydrocephalus requires careful prenatal evaluation, including genetic testing, due to its complex progression and association with other anomalies. While prognosis varies, isolated cases may benefit from emerging prenatal surgical interventions.

Area of Science:

  • Medical Science
  • Fetal Medicine
  • Pediatric Neurology

Background:

  • Fetal hydrocephalus is a dynamic condition with poorly understood natural progression.
  • It is frequently associated with other intracranial and extracranial anomalies.
  • Mild ventricular enlargement may be a normal variant, necessitating careful evaluation.

Purpose of the Study:

  • To outline the diagnostic and prognostic considerations for fetal hydrocephalus.
  • To discuss therapeutic options, including potential prenatal surgical interventions.
  • To highlight the importance of detailed prenatal evaluation and genetic counseling.

Main Methods:

  • Detailed anatomic survey during prenatal evaluation.
  • Genetic amniocentesis for genetic counseling.

Related Experiment Videos

  • Differential diagnosis including communicating hydrocephalus and X-linked hydrocephalus.

    • Main Results:

    • Prognosis is poor with multiple associated anomalies, especially central nervous system (CNS) anomalies.
    • Isolated hydrocephalus may warrant gender determination for X-linked considerations.
    • A subset of fetuses with isolated hydrocephalus might benefit from prenatal surgical intervention.

    Conclusions:

    • Prenatal diagnosis of ventricular enlargement requires comprehensive evaluation.
    • Therapeutic options, including potential antenatal surgery, should be discussed with patients.
    • Advancements in fetal medicine are expanding possibilities for managing fetal hydrocephalus.