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Downstream processing of proteins.

T Becker1, J R Ogez, S E Builder

  • 1Genentech, Inc., South San Francisco, California 94080, USA.

Biotechnology Advances
|January 1, 1983
PubMed
Summary
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This review details protein recovery from fermented materials since 1979, highlighting advances in cell disruption, separation, and purification techniques. Innovations are most notable in chromatography and tangential-flow filtration for efficient bioprocessing.

Area of Science:

  • Biotechnology
  • Biochemical Engineering
  • Protein Chemistry

Background:

  • Industrial protein production relies on efficient recovery from complex fermented matrices.
  • Post-1979 literature reveals significant evolution in downstream processing methodologies.
  • Optimizing protein recovery is crucial for economic viability in biomanufacturing.

Purpose of the Study:

  • To comprehensively review advancements in protein recovery from fermented sources since 1979.
  • To identify key innovations and trends in downstream processing techniques.
  • To provide a resource for researchers and professionals in bioprocessing.

Main Methods:

  • Literature review of scientific publications from 1979 to present.
  • Categorization of recovery processes into distinct stages: cell disruption, extraction, separation, and finishing.

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  • Analysis of technological developments within each stage, with a focus on chromatography and filtration.

    • Main Results:

    • Significant progress observed across all protein recovery stages.
    • Chromatography techniques have seen substantial innovation in resolution and capacity.
    • Tangential-flow filtration has emerged as a key technology for scalable separations and concentration.

    Conclusions:

    • The field of protein recovery has advanced considerably, driven by innovations in separation technologies.
    • Chromatography and tangential-flow filtration represent areas of particularly dynamic development.
    • Continued innovation in these areas is essential for improving the efficiency and yield of biopharmaceutical production.