Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell death and tendinopathy.

Jun Yuan1, Min-Xia Wang, George A C Murrell

  • 1Orthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, NSW 2217, Australia.

Clinics in Sports Medicine
|October 17, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does tear size influence factors associated with early retear, satisfaction, and functional outcomes after arthroscopic rotator cuff repair?

PloS one·2026
Same author

Is elastography feasible in torn rotator cuffs before surgery?

JSES international·2026
Same author

Correction: Is it enough to utilize a single anchor for repair of rotator cuff tears ≤ 3 * 3 cm²?

PloS one·2026
Same author

The effectiveness of arthroscopically inserted onlay bioinductive implant on revision rotator cuff repair in workers' compensation patients: a case-controlled cohort study with minimum 2-year follow-up.

Journal of shoulder and elbow surgery·2025
Same author

Postoperative stiffness and rotator cuff tendon healing: a narrative review.

JSES reviews, reports, and techniques·2025
Same author

Pain and gain-an evaluation of the role of cytokines in rotator cuff healing.

Journal of shoulder and elbow surgery·2025
Same journal

"Women's Sports Is Still in its Infancy." - Billie Jean King.

Clinics in sports medicine·2026
Same journal

Treatment Considerations in the Female Athlete.

Clinics in sports medicine·2026
Same journal

Sports Considerations Related to Pregnancy and Postpartum.

Clinics in sports medicine·2026
Same journal

Management of Bone Stress Injuries: A Holistic Approach.

Clinics in sports medicine·2026
Same journal

Relative Energy Deficiency in Sport.

Clinics in sports medicine·2026
Same journal

Gymnastics-Related Injuries for the Female Athlete.

Clinics in sports medicine·2026
See all related articles

Excessive apoptosis, or programmed cell death, is observed in degenerative tendons, potentially impairing collagen synthesis and increasing rupture risk. Understanding this process may lead to new tendinopathy treatments.

Area of Science:

  • Cell Biology
  • Orthopedics
  • Biomedical Engineering

Background:

  • Apoptosis and necrosis are key cell death types.
  • Tendinopathy involves tendon injury from various factors.
  • Excessive apoptosis is noted in degenerative tendons.

Purpose of the Study:

  • To investigate the role of apoptosis in degenerative tendinopathy.
  • To understand how apoptosis affects tendon healing and integrity.

Main Methods:

  • Analysis of cell death pathways in tendon tissue.
  • Biochemical and morphological characterization of apoptotic cells.
  • Correlation of apoptosis levels with tendon degeneration and rupture risk.

Main Results:

Related Experiment Videos

  • Increased apoptotic tendon cells are present in degenerative tissue.
  • Apoptosis may negatively impact collagen synthesis and repair processes.
  • Impaired protein synthesis due to apoptosis can weaken tendons.

Conclusions:

  • Excessive apoptosis is a significant factor in tendinopathy.
  • Targeting apoptosis pathways could offer novel treatment strategies for tendinopathy.
  • Further research into apoptosis mechanisms is crucial for effective intervention.