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[Hemodialysis and ferritinemia].
1Laboratoire de biochimie, hôpital Broussais, Paris, France.
Annales De Biologie Clinique
|January 1, 1992
Summary
Iron deficiency is common in dialysis patients, and while iron treatments are given, overload can occur. Serum ferritin accurately reflects iron stores and behaves similarly in both healthy and dialysis patients across different tests.
Area of Science:
- Nephrology
- Hematology
- Clinical Chemistry
Background:
- Iron deficiency is prevalent in patients with chronic kidney disease and those undergoing hemodialysis.
- Iron supplementation or transfusions are common, but can lead to iron overload.
- Serum ferritin is a key indicator of iron stores, despite analytical variability.
Purpose of the Study:
- To evaluate the performance of four commercial reagents for serum ferritin measurement.
- To compare serum ferritin levels and reagent behavior in healthy individuals versus hemodialysis patients.
Main Methods:
- Analysis of serum ferritin using four distinct commercial reagent kits.
- Inclusion of healthy subjects and hemodialysis patients (children and adults), both treated and untreated for iron deficiency.
Main Results:
- Serum ferritin measurement showed consistent behavior across the four reagents in both healthy and hemodialysis patient groups.
- No significant differences in reagent performance were observed between healthy and hemodialysis populations, irrespective of iron treatment status.
Conclusions:
- Commercial serum ferritin assays perform reliably and comparably across healthy and hemodialysis populations.
- Serum ferritin remains a valuable and consistent biomarker for assessing iron status in patients with chronic kidney disease on hemodialysis.