Heritability and candidate genes for endometriosis
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Updated: Aug 30, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Joe Leigh Simpson1, Farideh Bischoff
1Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA. jsimpson@bcm.tmc.edu
Abstract:
Endometriosis is inherited in polygenic/multifactorial fashion, with recurrence risks of 5-7% for first-degree relatives. The current task is to determine the number and location of causative genes. This review initially supports the basis for polygenic/multifactorial inheritance and then outlines genome-wide strategies for identifying causative genes. Potential candidate genes are surveyed, and discrepant results emphasized. Finally, a hypothesis for endometriosis, having a multi-step pathogenesis analogous to the pathogenesis of neoplasia, is considered.
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