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Nimesulide-modified gum karaya solid mixtures: preparation, characterization, and formulation development.

G V Murali Mohan Babu1, N Ravi Kumar, K Himasankar

  • 1Division of Industrial Pharmacy, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India.

Drug Development and Industrial Pharmacy
|October 23, 2003
PubMed
Summary
This summary is machine-generated.

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This study enhanced nimesulide (NS) dissolution using modified gum karaya (MGK). Solid dispersions showed the highest dissolution improvement, but cogrinding mixtures offered practical commercialization potential.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Nimesulide (NS) exhibits poor aqueous solubility, limiting its therapeutic efficacy.
  • Modified gum karaya (MGK) is explored as a carrier to enhance the dissolution rate of poorly soluble drugs.

Purpose of the Study:

  • To prepare solid mixtures of nimesulide and modified gum karaya to improve nimesulide's dissolution rate.
  • To investigate the impact of drug-carrier ratios and preparation methods on nimesulide dissolution.

Main Methods:

  • Solid mixtures were prepared using cogrinding, physical mixing, kneading, and solid dispersion techniques.
  • Characterization included Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD).
  • In vitro dissolution rate studies and equilibrium solubility studies were conducted.

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Main Results:

  • Nimesulide dissolution rate was concentration-dependent on MGK, with an optimal 1:4 (NS:MGK) ratio.
  • All preparation methods significantly improved NS dissolution compared to the pure drug.
  • Solid dispersion yielded the maximum dissolution rate enhancement, followed by kneading, cogrinding, and physical mixing.

Conclusions:

  • Modified gum karaya effectively enhances nimesulide dissolution.
  • Solid dispersion is the most effective method for improving dissolution, but cogrinding offers a viable alternative for commercial tablet formulation due to practical considerations.