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Basal norepinephrine in depersonalization disorder.

Daphne Simeon1, Orna Guralnik, Margaret Knutelska

  • 1Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. daphne.simeon@mssm.edu

Psychiatry Research
|October 24, 2003
PubMed
Summary

This study explored norepinephrine in depersonalization disorder (DPD). Findings suggest heightened noradrenergic activity with anxiety, but a decline in norepinephrine as depersonalization severity increases.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Autonomic Nervous System Function

Background:

  • Noradrenergic dysregulation is documented in PTSD, but its role in dissociative disorders remains unclear.
  • Depersonalization disorder (DPD) is a dissociative condition characterized by persistent feelings of detachment from oneself.

Purpose of the Study:

  • To investigate basal norepinephrine levels in individuals diagnosed with depersonalization disorder (DPD).
  • To explore the relationship between norepinephrine levels and the severity of depersonalization symptoms.

Main Methods:

  • A preliminary study comparing nine subjects with DSM-IV DPD (without PTSD) to nine healthy comparison (HC) subjects.
  • Norepinephrine was measured using 24-hour urine collection and three serial plasma determinations.

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  • Depersonalization severity and anxiety levels were assessed.

    • Main Results:

    • No significant differences in plasma norepinephrine levels were found between DPD and HC groups.
    • The DPD group showed significantly higher urinary norepinephrine, particularly when anxiety was not factored out.
    • A strong inverse correlation (r=-0.88) was observed between urinary norepinephrine and depersonalization severity in the DPD group.
    • Norepinephrine and cortisol levels were not intercorrelated.

    Conclusions:

    • While dissociation with anxiety may involve increased noradrenergic tone, severe depersonalization is associated with reduced basal norepinephrine.
    • Findings align with existing research suggesting autonomic blunting in dissociative states.
    • Further research is warranted to elucidate the complex role of the noradrenergic system in DPD.