Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ebf gene function is required for coupling neuronal differentiation and cell cycle exit.

Mario Garcia-Dominguez1, Christophe Poquet, Sonia Garel

  • 1Unité 368 de l'Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris 05, France.

Development (Cambridge, England)
|October 24, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Vitamin D in Neuropathic Pain: Biological Mechanisms and Clinical Relevance.

International journal of molecular sciences·2026
Same author

IL-23 blockade: A strategy for managing pain-related inflammatory diseases.

International review of cell and molecular biology·2026
Same author

Neuropathic Pain: Mapping the miRNA Landscape.

Non-coding RNA·2026
Same author

Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain.

Biomolecules·2026
Same author

Moving Toward Objective Diagnosis in Fibromyalgia: Emerging Biomarkers and Digital Phenotyping Tools.

Biomedicines·2026
Same author

Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes.

Research square·2026
Same journal

Retinoic acid and FGF signaling interact to control elongation and lineage specification in a mouse gastruloid model.

Development (Cambridge, England)·2026
Same journal

Expanding the C. elegans toolkit with gonad explants.

Development (Cambridge, England)·2026
Same journal

Nuclear Factor Y controls nutrient-adaptive epithelial growth by regulating mTOR in the Drosophila midgut.

Development (Cambridge, England)·2026
Same journal

Primordial germ cells differentially contribute to the germline in zebrafish.

Development (Cambridge, England)·2026
Same journal

Dissecting planar and vertical organiser signals in early chick neural development.

Development (Cambridge, England)·2026
Same journal

Real-time transcriptomic profiling of hPSC-derived cartilage during development identifies a key role for the extracellular matrix in homeostasis and protection.

Development (Cambridge, England)·2026
See all related articles

Ebf genes are master regulators of neurogenesis, controlling neuronal differentiation and migration. They couple these processes to cell cycle exit in the central nervous system.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Helix-loop-helix transcription factors of the Ebf/Olf1 family are implicated in neurogenesis.
  • Their precise roles in central nervous system development remain unclear.

Purpose of the Study:

  • To characterize Ebf gene function in chick spinal cord and hindbrain neurogenesis.
  • To elucidate the role of Ebf genes in the neurogenic cascade.

Main Methods:

  • Functional analysis using gain- and loss-of-function experiments in chick embryos.
  • Investigating the coupling of cell cycle exit, neuronal differentiation, and migration.

Main Results:

  • Ebf gene function is necessary for initiating neuronal differentiation and mantle layer migration.

Related Experiment Videos

  • Ebf genes are not required for cell cycle exit but couple it to differentiation and migration.
  • Mutual activation between proneural and Ebf genes suggests a role in stabilizing cell fate.
  • Gain-of-function data suggest Ebf genes may specify neuronal subtypes.

    • Conclusions:

    • Ebf genes act as master controllers of neuronal differentiation and migration, linking them to cell cycle exit.
    • Ebf genes play crucial roles in the stabilization of neuronal commitment.
    • Ebf genes may also be involved in regional neuronal subtype specification within the CNS.