Related Experiment Video
Updated: Aug 30, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
[Effects of corticosteroid on eosinophils and expression of transforming growth factor beta 1 in nasal polyps]
Zezhang Tao1, Yonggang Kong, Bokui Xiao
1Department of Otolaryngology-Head and Neck Surgery, People's Hospital of Wuhan University, Wuhan 430060.
Objective:
To observe the effects of systemic steroids on the infiltration of eosinophils and the expression of TGF beta 1 in nasal polyps.
Method:
The SP immunohistochemical methods were applied to explore the expression of TGF beta 1 in nasal polyps before and after corticosteroids use; the optical density of positive cells in mucosal epithelia, eosinophils, glandular epithelium, vascular endothelial, matrix and mucous membrane was measured by using HPIAS-1,000 image-conduct system.
Result:
The expression of TGF beta 1 was positive in nasal polyps. The number of eosinophils and the expression of TGF beta 1 was significantly reduced in nasal polyps after treated with corticosteroids compared with pre-treated.
Conclusion:
The effects of systemical steroid use on the nasal polyps may depend on decreasing the infiltration of eosinophils and the expression of TGF beta 1.
Related Concept Videos
Cushing Syndrome II: Pathophysiology
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
TGF - β Signaling Pathway