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[Hypopituitarism and antiphospholipid syndrome].

O Essaïs1, H Ouertani, C Bouzid

  • 1Service d'Endocrinologie-Diabétologie, Hôpital Militaire Tunis, Tunisie.

Annales D'Endocrinologie
|November 5, 2003
PubMed
Summary

Antiphospholipid syndrome can cause rare endocrine disorders like hypopituitarism. Early screening for antiphospholipid syndrome is crucial in patients with hypopituitarism and thrombosis history.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Immunology

Background:

  • Antiphospholipid syndrome (APS) is an autoimmune disorder typically associated with thrombosis and pregnancy complications.
  • Endocrine dysfunctions in APS are uncommon, with Addison's disease being the most frequently reported.
  • Recent literature suggests a possible link between primary APS and hypopituitarism.

Observation:

  • A young female patient developed neuroendocrine symptoms postpartum.
  • Hormone assessment revealed complete anterior hypopituitarism.
  • The patient tested positive for antiphospholipid antibodies.

Findings:

  • This case highlights a rare presentation of hypopituitarism secondary to antiphospholipid syndrome.
  • The patient's clinical, biological, and radiological features align with previously reported cases.

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  • The postpartum onset suggests a potential trigger or exacerbation of the condition.

    • Implications:

    • Screening for antiphospholipid syndrome should be considered in the etiological investigation of hypopituitarism, especially in patients with a history of recurrent thrombosis.
    • This case broadens the understanding of endocrine manifestations of antiphospholipid syndrome.
    • Further research is warranted to elucidate the pathogenic mechanisms linking APS and hypopituitarism.