Hematologic changes in Down's syndrome during infantile and early childhood period

"Twenty cases of Down's syndrome and 25 age-matched normal controls were subjected to hematologic study including Hb, R.B.Cs, W.B.Cs., HbF., bone marrow, protein electrophoresis and chromosomal study. Peripheral blood and bone marrow showed noticeable increase in granulocytes, increase in staff, and decrease in lymphocytes in mongols as compared to the controls. HbF was lower than normal in 18 cases. The other two showed abnormally high HbF. Protein electrophoretic study showed normal pattern except one case in which a remarkable decrease in the Beta and Gamma Fraction was noticed".