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The auricular VX2 carcinoma--an animal model for sentinel node concept
A A Dünne1, A Schmidt, C Kuropkat
1Department of Otolaryngology, Head and Neck Surgery, Philipps-University of Marburg, Deutschhausstr. 3, 35037 Marburg, Germany.
In Vivo (Athens, Greece)
|November 6, 2003
Summary
The auricular VX2 carcinoma in rabbits effectively models sentinel node (SN) metastasis in head and neck squamous cell carcinoma (HNSCC). This model simulates lymphogenic spread, crucial for understanding SN biopsy efficacy.
Area of Science:
- Oncology
- Surgical Pathology
- Animal Models
Background:
- The sentinel node (SN) concept is increasingly vital in clinical oncology.
- Evaluating the auricular VX2 carcinoma as a model for SN concept simulation is crucial.
Purpose of the Study:
- To assess the applicability of the auricular VX2 carcinoma in New Zealand white rabbits as an animal model for simulating the sentinel node concept.
- To investigate the lymphogenic metastatic spread in this model.
Main Methods:
- Lymphatic drainage of the auricle was mapped using blue dye and immunofluorescence-marked colloids in 8 rabbits.
- Metastatic spread of auricular VX2 carcinomas was examined in 28 rabbits over 32 days.
Main Results:
- Lymphogenic metastasis was confined to the parotideal lymph node (SN) for up to 21 days.
- After 28 days, SN integrity loss led to metastasis in secondary lymph nodes and subsequent hematogenic spread.
Conclusions:
- The auricular VX2 carcinoma in New Zealand white rabbits is a suitable model for simulating lymphogenic metastasis and the SN concept in head and neck squamous cell carcinoma (HNSCC).