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Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
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Boronate titanium alkylidene reagents for diversity-based synthesis of benzofurans

Gordon J McKiernan1, Richard C Hartley

  • 1Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland.

Organic Letters
|November 7, 2003
PubMed

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One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
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