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Do macrophage innate immune receptors enhance atherogenesis?
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England.
Developmental Cell
|November 7, 2003
Abstract:
Macrophages play a central role in both innate immunity to infection and atherosclerosis. Castrillo and colleagues report that selected microbial agonists for Toll-like receptors strongly inhibit LXR-mediated cholesterol efflux from macrophages. TLR-LXR crosstalk could explain how nonspecific microbial infections promote atherogenesis.