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Updated: Aug 30, 2026

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
Cytomegalovirus infection in liver transplant recipients
Jun Fan1, Wei-Hang Ma, Jing Qian
1Institute of Infectious Diseases and Key Laboratory of Viral Infectious Diseases, Ministry of Health, Zhejiang University School of Medicine, Hangzhou 310003, China. fjjc@yeh.net
Objective:
To explore cytomegalovirus (CMV) infection in recipients of liver transplantation (LT).
Methods:
30 recipients of LT were screened for the appearance of CMV infection by using ELISA to test anti-CMV-Ab from serum samples and using immunohistochemistry method to test CMV antigen expression and nested-PCR to amplify CMV-DNA from blood samples.
Results:
Four of 243 samples taken from 30 recipients came out positive of anti-CMV IgG and anti-CMV IgM with a positive rate of 100% and 1.6% respectively. 85 samples resulted in CMV antigen expression (35.0%) with the average antigen index being 4.2+/-3.1/5 X 10(4) WBC. Besides, 99 samples were found to be positive by nested-PCR with a positive rate of 40.7%. 61 samples were found to be simultaneously positive in test of CMV antigen and DNA, with a rate of 25.1%.
Conclusions:
Infection of CMV is common in recipients of LT. Simultaneous screening of anti-CMV-Ab, CMV-Ag and CMV-DNA after liver transplantation is very important for early diagnosis of CMV infection.
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