Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rap1 GTPase: functions, regulation, and malignancy.

Masakazu Hattori1, Nagahiro Minato

  • 1Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto 606-8501.

Journal of Biochemistry
|November 11, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interleukin-7 receptor activation in interstitial macrophages promotes lung fibrosis through secreted phosphoprotein 1.

American journal of respiratory cell and molecular biology·2025
Same author

Sipa1 Drives a Maladaptive Fibroblast-Myeloid Axis After Myocardial Infarction.

Circulation research·2025
Same author

Aligning cellular and molecular components in age-dependent tertiary lymphoid tissues of kidney and liver.

PloS one·2025
Same author

Senescence-associated T cells in immunosenescence and diseases.

International immunology·2024
Same author

Non-cell-autonomous suppression of tumor growth by RECK in immunocompetent mice.

Journal of cellular physiology·2024
Same author

Protocol for the isolation of mouse senescence-associated CD4<sup>+</sup> T cells using flow cytometry and functional assays.

STAR protocols·2023
Same journal

Estrogen-related receptor γ functions as a novel corepressor of androgen receptor by destabilizing receptor conformation and blocking coactivator recruitment.

Journal of biochemistry·2026
Same journal

Chromatin dynamics and cellular energy homeostasis.

Journal of biochemistry·2026
Same journal

Nutrigenomic Regulation of One-Carbon Metabolism and the Circadian Clock in Health and Disease.

Journal of biochemistry·2026
Same journal

Time to rethink circadian rhythms beyond the transcriptome.

Journal of biochemistry·2026
Same journal

BNIP3/NIX-dependent mitophagy: molecular mechanisms and physiological roles.

Journal of biochemistry·2026
Same journal

Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation.

Journal of biochemistry·2026
See all related articles

Rap1, a small GTPase, regulates cell functions like integrin activation and ERK signaling. Its dysregulation is linked to malignancy, highlighting its crucial role in health and disease.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Signal Transduction

Background:

  • Rap1 is a small GTPase involved in diverse cellular processes.
  • Its activation is tightly regulated by guanine nucleotide exchange factors and GTPase-activating proteins.
  • Rap1 plays roles in integrin activation and ERK signaling pathways.

Purpose of the Study:

  • To explore the multifaceted roles of Rap1 in cellular functions.
  • To investigate the implications of Rap1 dysregulation in disease, particularly malignancy.
  • To synthesize recent findings on the physiological and pathological significance of Rap1.

Main Methods:

  • Literature review of recent extensive research on Rap1.
  • Analysis of Rap1's involvement in signaling pathways (e.g., Ras-mediated ERK activation).

Related Experiment Videos

  • Examination of Rap1's role in integrin activation and cellular adhesion.

    • Main Results:

    • Rap1 activation is controlled spatio-temporally by specific regulatory proteins.
    • Rap1 can modulate ERK activation either by interfering with Ras or independently.
    • Rap1 is a key activator of integrins, influencing cellular functions.
    • Dysregulation of Rap1 signaling is implicated in the development of malignancy.

    Conclusions:

    • Rap1 is a critical regulator of fundamental cellular processes.
    • Aberrant Rap1 activation contributes to the pathogenesis of cancer.
    • Further research into Rap1's functions is essential for understanding both normal physiology and disease states.