Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear transfer: progress and quandaries.

Xuemei Li1, Ziyi Li, Alice Jouneau

  • 1Institute of Zoology, Chinese Academy of Science, Beijing 100080, PR China. lixm@panda.ioz.ac.cn

Reproductive Biology and Endocrinology : RB&E
|November 14, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment and Characterization of Bovine Trophoblast Stem Cells Growing as Adherent Cells or Vesicles.

Molecular reproduction and development·2025
Same author

Short-Term Exposure to Culture Media Used in Human ART Shapes Early Calcium Oscillations in ICSI-Fertilized Mouse Oocytes and Impacts Adult Phenotype.

Reproductive medicine and biology·2025
Same author

Transcriptomic profiling reveals similarities between equine IVF and ICSI embryos.

Theriogenology·2025
Same author

Patient Preferences and Understanding of Glaucoma Treatment: A Nationwide Survey by the French Glaucoma Society.

Advances in therapy·2025
Same author

ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats.

Human molecular genetics·2024
Same author

Comparison of In Vitro Corneal Permeation and In Vivo Ocular Bioavailability in Rabbits of Three Marketed Latanoprost Formulations.

European journal of drug metabolism and pharmacokinetics·2023
Same journal

Multi-dimensional predictive model for diminished ovarian reserve in Hashimoto's thyroiditis: development and application.

Reproductive biology and endocrinology : RB&E·2026
Same journal

Prospective clinical validation of targeted long-read sequencing for preimplantation genetic testing of α-thalassaemia.

Reproductive biology and endocrinology : RB&E·2026
Same journal

Mice lacking NF-ĸB1 undergo premature ovarian aging.

Reproductive biology and endocrinology : RB&E·2026
Same journal

Association of celiac disease with menstrual and hormonal disturbances: a systematic review and meta-analysis.

Reproductive biology and endocrinology : RB&E·2026
Same journal

Diagnosis-dependent metabolic reprogramming of follicular fluid.

Reproductive biology and endocrinology : RB&E·2026
Same journal

Retraction Note: Evaluation of safety margins of chenopodium album seed decoction: 14-day subacute toxicity and microbicidal activity studies.

Reproductive biology and endocrinology : RB&E·2026
See all related articles

Cloning mammals via nuclear transfer faces low efficiency due to incomplete epigenetic reprogramming. Understanding these reprogramming events is crucial for improving cloned embryo development and overcoming defects.

Area of Science:

  • Reproductive biology and developmental science.

Background:

  • Mammalian cloning via nuclear transfer is advancing genetically defined animal model development.
  • Low efficiency and developmental failures in cloned embryos are significant hurdles.

Purpose of the Study:

  • To investigate the incomplete understanding of epigenetic reprogramming in cloned embryos.
  • To identify molecular events crucial for efficient donor genome reprogramming after nuclear transfer.

Main Methods:

  • The study focuses on understanding the biological processes controlling epigenetic reprogramming.
  • It emphasizes screening strategies for nuclear transfer protocols and identifying molecular parameters for developmental potential.

Main Results:

  • Incomplete epigenetic reprogramming is the primary cause of developmental failure in cloned embryos.

Related Experiment Videos

  • Gene dysregulation is frequently associated with reprogramming failures.

    • Conclusions:

    • A deeper understanding of molecular events in donor genome reprogramming is essential.
    • This knowledge will help identify defects in cloned embryos and improve cloning technology applications.