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Updated: Aug 4, 2026

Curtain Flow Column: Optimization of Efficiency and Sensitivity
Published on: June 12, 2016
Circular asymmetrical flow field-flow fractionation for the semipreparative separation of particles
Michael Maskos1, Wolfgang Schupp
1Institut für Physikalische Chemie, Universität Mainz, Welder Weg 11, D-55099 Mainz, Germany. maskos@uni-mainz.de
Abstract:
A new technique for the separation and characterization of particles and polymers based on asymmetrical flow field-flow fractionation was developed. The new circular asymmetrical flow field-flow fractionation instrument (CAFFFE) resembles a quasi-parallel arrangement of 12 individual flow channels. As compared to the classical asymmetrical flow field-flow fractionation (AF-FFF), which can be used so far only for analytical separation and characterization of particles and polymers, the CAFFFE allows the introduction of higher amounts of sample into the channel in a single run so that semipreparative to preparative separation becomes possible. This was demonstrated by the separation of polymer latex standards.
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