[Architecture of the heart and heart failure]

One of the scientific missions of the XXI century is the integration of the basic research with the clinical medicine. One example in the change of century is heart failure (HF). The macroscopic anatomy, the cardiac physiology and the molecular biology have modified and enriched the conception of HF. The enigma of cardiac architecture has been solved. The heart works as a piston of explosion machine, a piston in which its walls twisted while shortening ejecting the blood in systole and sucking the blood in diastole. The HF is a single process with three phases; umpired relaxation, diastolic failure and diastolic and systolic failure all together.