Related Experiment Video

Updated: Aug 30, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

[Ischemic hepatitis in patients with heart failure]

J Muñoz-Rodríguez1, J M Tricas Leris, V Andreu Solsona

  • 1Servicio de Medicina Interna, Hospital de Mollet, Mollet del Vallès, Barcelona, Spain. 28587fmr@comb.es

Anales De Medicina Interna (Madrid, Spain : 1984)
|November 20, 2003
PubMed

Insights

Ischemic hepatitis, marked by elevated liver enzymes, occurs when hepatic blood flow is reduced, often in heart failure patients. Diagnosis requires excluding other hepatitis causes, with centrilobular necrosis as a key feature.

Area of Science:

  • Hepatology
  • Cardiology
  • Pathology

Background:

  • Ischemic hepatitis presents as reversible elevation of liver enzymes (AST, ALT) due to reduced hepatic blood flow.
  • It is frequently observed in patients with underlying heart failure.
  • Diagnosis necessitates excluding other causes of hepatitis, such as viral infections and drug toxicity.

Observation:

  • This study details three cases of ischemic hepatitis encountered within a single year.
  • These cases were identified within the medical service of the reporting institution.
  • The study period covered one year of patient admissions.

Findings:

  • Ischemic hepatitis was diagnosed in 2.7% of all heart failure patients admitted during the study period.
  • Centrilobular necrosis was identified as the primary histologic finding in these cases.
  • The observed cases highlight the clinical relevance of ischemic hepatitis in heart failure management.

Implications:

  • Early recognition of ischemic hepatitis is crucial for managing patients with heart failure.
  • Understanding the prevalence and characteristics of ischemic hepatitis can improve patient outcomes.
  • Further research into the mechanisms and treatment of ischemic hepatitis in cardiac patients is warranted.

More Related Videos

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction03:42

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice05:08

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Published on: October 3, 2019

Related Concept Videos

Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...