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Vulvovaginal trichosporonosis
Paul Makela1, Debbie Leaman, Jack D Sobel
1Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA. pmakela@med.wayne.edu
Infectious Diseases in Obstetrics and Gynecology
|November 25, 2003
Summary
Trichosporon inkin is rarely pathogenic in vaginal infections, often colonizing asymptomatically. When symptoms occur, it
Area of Science:
- Mycology
- Infectious Diseases
- Gynecology
Background:
- Isolation of Trichosporon species from vaginal secretions is uncommon.
- Limited data exists on the pathogenic role of Trichosporon species in vulvovaginal infections.
- Understanding the clinical significance of Trichosporon in vaginal flora is crucial.
Purpose of the Study:
- To determine the pathogenic role of Trichosporon species in vulvovaginal infections.
- To analyze cases of Trichosporon isolation from vaginal secretions.
Main Methods:
- Retrospective chart review of patients from the W.S.U. Vaginitis Clinic.
- Identification of patients with positive vaginal cultures for Trichosporon species.
- Analysis of clinical data, co-infections, and in-vitro susceptibility.
Main Results:
- 13 patients had 18 positive vaginal cultures for Trichosporon species (T. inkin) between 1986-2001.
- Positive cultures often had low yeast counts and were frequently associated with other diagnoses or asymptomatic colonization.
- T. inkin was resistant to flucytosine but susceptible to azoles; pathogenic role established in only one case.
Conclusions:
- Trichosporon inkin is an occasional finding in vulvovaginal cultures and is typically a non-pathogen.
- Transient colonization occurs in women with altered vaginal flora and increased pH.
- Pathogenic consequences of Trichosporon colonization are rare.