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Vascular wall kininogen concentration is inversely related to intrinsic kininogenase in spontaneously hypertensive
1Evans Memorial Department of Clinical Research, University Hospital, Boston University School of Medicine, MA 02118.
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|January 1, 1992
Abstract:
We determined kininogen concentration and kininogenase activity in the blood-free, aorta homogenates of 15 week old spontaneously hypertensive rats (SHR) and in their age-matched wistar kyoto (WKY) controls. Active kininogenase in the SHR was only 18% of the WKY controls. Thus, the kininogen concentration was inversely related to kininogenase activity suggesting a local interaction of these components and possible generation of kinins within the vascular wall.