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Updated: Aug 30, 2026

Monitoring Electroporation-Induced Changes in Action Potential Generation in Genetically Engineered Tet-On Spiking HEK cells
Published on: September 6, 2024
Controlling the active properties of excitable cells
1Department of Biochemistry, 513 Parnassus Avenue, Room HSE901, University of California San Francisco, San Francisco, California 94143, USA.
Abstract:
Molecular perturbations of neurons, including genetic knockout and transgenic approaches, have provided insight into the cellular processes underlying neuronal function and plasticity. A detailed understanding of how individual neurons participate in the circuitry that controls behavior, however, will require the ability to experimentally manipulate the active properties of neurons in vivo. Recent technologies have greatly advanced our experimental ability to modulate the active properties of neurons with spatial and temporal precision; technical advances have been applied to the investigation of a diverse array of neurobiological questions.
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