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Altered expression of vascular endothelial growth factor and FLK-1 receptor in chronically hypoxic rat carotid body

J Chen1, Bruce Dinger, R Jyung

  • 1Department of Physiology University of Utah School of Medicine, USA.

Advances in Experimental Medicine and Biology
|November 26, 2003
PubMed
Abstract

No abstract available in PubMed .

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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