Endogenous dopamine modulates corticopallidal influences via GABA
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Updated: Aug 30, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
Published on: August 10, 2012
V V Raevskii1, G S Dawe, J D Stevenson
1Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerov Street, 117865 Moscow, Russia.
Abstract:
Acute experiments on Sprague-Dawley rats were performed to study the effects of local application of D1 and D2 receptor antagonists (SCH 23390 and raclopride) on the responses of neurons in the globus pallidus induced by stimulation of the somatosensory cortex. SCH 23390 induced short-latency inhibition in response to stimulation of the cortex and blocked long-latency inhibition. Application of raclopride suppressed short-latency inhibition and induced a long-latency inhibitory response to stimulation of the cortex. It is suggested that these changes are based on modulation of GABA release from striopallidal terminals by endogenous dopamine.
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